Back in print for the first time in years, this spectacular space odyssey features the World's Greatest Super-Heroes in a battle for all existence. When it is discovered that the long sought-after Anti-Life Equation is in actuality a living sentience that is attempting to cross dimensions and destroy reality, the greatest heroes of the world are called upon to stop its emergence. As agents of the Anti-Life invade the universe, Superman, Batman, Green Lantern, and the Martian Manhunter form four separate teams to prevent the destruction of two worlds which would facilitate the arrival of the Death entity. But even after their heroic stand results in a hard fought victory, a final betrayal by Darkseid may spell doom for all living beings.